Asthma-COPD Overlap Prevalence, Severity in Low- and Middle-Income Countries

By | November 6, 2018

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Old age was also a risk factor for asthma-COPD overlap in low- and middle-income countries.
Old age was also a risk factor for asthma-COPD overlap in low- and middle-income countries.

Low- and middle-income countries may face asthma-COPD overlap that is comparably prevalent and more severe than that reported in high-income countries, according to a study published in The Journal of Allergy and Clinical Immunology. Environmental exposures, such as smoke from biomass fuel, could play a significant role in contributing to the disorder.

This analysis included data from 11,923 participants from 4 separate studies conducted in 6 low- and middle-income countries. The overall rate of asthma-COPD overlap was 3.8%, with a maximum prevalence of 7.8% in Matlab, Bangladesh. Smoke from biomass fuel was a significant risk factor for asthma-COPD overlap, with an odds ratio of 1.48 (95% CI, 0.98-2.23) in individuals with household exposure. Primary or lower education led to a relative odds ratio of 1.35 (95% CI, 1.07-1.70), and smoking cigarettes led to an odds ratio of 1.28 per 10 pack-years (95% CI, 1.22-1.34).

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Asthma-COPD overlap correlated with acute spirometric deficiencies relative to asthma alone (-1.61 z-scores on forced expiratory volume in 1 second [FEV1]; 95% CI, -1.48 to -1.75) or COPD alone (-0.94 z-scores on FEV1; 95% CI, -0.78 to -1.10). Asthma-COPD overlap was also linked with prebronchodilator FEV1/forced vital capacity (FVC) z-scores 2.5 lower than those in the general population or those with only asthma, and 0.61 lower than patients with only COPD.

Old age was also a risk factor, with a prevalence of 1.1% (95% CI, 0.8%-1.7%) in participants younger than 45 years, 3.9% (95% CI, 3.4%-4.4%) in participants between 45 and 59 years, 4.9% (95% CI, 4.2%-5.7%) in participants between 60 and 74 years, and 5.7% (95% CI, 3.9%-8.3%) in participants older than 75 years.

The studies covered by this analysis took place in 12 different settings, and participants were between the ages 35 and 92. Asthma was defined as physician diagnosis, past-year medication use, or wheeze, while COPD was defined as subnormal postbronchodilator FEV1/FVC levels. Chi-squared tests were used to compare categorical data and ANOVA tests were used to compare continuous data.

[W]e found an increased proportion of those with asthma or COPD who show features consistent with overlap and a high rate of severe obstruction among those with [asthma-COPD overlap]. Thus, the results of this analysis indicate that [asthma-COPD overlap] may be as prevalent and the associated respiratory deficits more severe in [low- and middle-income countries], which are experiencing the simultaneous burdens of biomass exposure and high rates of urbanization and sprawl, than in high-income countries,” the researchers concluded.

Disclosures: Dr Wise reports personal fees and/or grants from several pharmaceutical corporations. For a full list of disclosures, please visit the reference.


Morgan BW, Grigsby MR, Siddharthan T, et al. Epidemiology and risk factors of asthma-COPD overlap in low- and middle-income countries [published online October 3, 2018]. J Allergy Clin Immunol. doi:10.1016/j.jaci.2018.06.052

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