Tag Archives: Essential

Essential Reads: Neurosteroids, Allopregnanolone and Vulnerability to Depression in Women

Women are twice as likely as men to suffer from a depressive disorder.  In addition, they are vulnerable to mood disorders associated with reproductive functioning, specifically premenstrual dysphoric disorder, perinatal depression, and perimenopausal depression. There is strong evidence to indicate that biological factors (genetic vulnerability, hormonal changes) and psychosocial factors (life stress) interact with one… Read More »

Essential Reads: Zuranolone for Postpartum Depression

In 2019, the Food and Drug Administration (FDA) approved brexanolone, marketed by Sage Therapeutics as Zulresso, as a treatment for postpartum depression (PPD).  As a neurosteroid, brexanolone represents a novel approach to the treatment of postpartum mood disorders.  One of the most exciting things about brexanolone is the rapidity of the response, with the initial… Read More »

Essential Reads: Lithium and Breastfeeding

Lithium is an important treatment option for women with bipolar disorder.  Because women with bipolar disorder are at high risk for relapse during the postpartum period, we typically recommend that women continue treatment with lithium throughout the postpartum period.  While this intervention clearly decreases risk for postpartum psychiatric illness, the use of lithium while breastfeeding… Read More »

Essential Reads: Measuring the Impact of Antenatal Depression on the Fetal Brain Using Neuroimaging

Previous studies have observed that the children of depressed mothers are more likely to have delays in cognitive development, worse school performance, higher rates of behavioral problems, and deficits in social-emotional regulation.  Children of depressed mothers are also more likely to experience adolescent depression.   Most studies have understood these vulnerabilities to neurodevelopmental problems and psychiatric… Read More »

Essential Reads: Strategies for the Prevention of Postpartum Depression

Postpartum depression (PPD) is a relatively common problem, affecting between 10% and 15% of women after delivery. Although it is difficult to reliably predict which women in the general population will experience postpartum depression, it is possible to identify certain subgroups of women who are at increased risk for postpartum affective illness. For example, women… Read More »