Using historical research that draws on new primary sources, I review the causes and course of the first, mainly iatrogenic amphetamine epidemic in the United States from the s through the s. The latest national surveys show that about 3 million Americans used amphetamine-type stimulants nonmedically in the past year, in the past week, and that to are addicted. The original amphetamine epidemic was generated by the pharmaceutical industry and medical profession as a byproduct of routine commercial drug development and competition. Searching for a decongestant and bronchodilator to substitute for ephedrine, in , biochemist Gordon Alles discovered the physiological activity of beta-phenyl-isopropylamine soon to be known as amphetamine. SKF marketed it as the Benzedrine Inhaler, a capped tube containing mg of oily amphetamine base and little else. For congestion, one was meant to inhale amphetamine vapor every hour as needed. SKF-funded Harvard psychiatrist Abraham Myerson played a particularly influential role, theorizing that amphetamine adjusted hormonal balance in the central nervous system by creating or amplifying adrenergic stimulation so as to promote activity and extra-version.
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Orlistat, which is legal in the UK, can cause highly embarrassing gastrointestinal symptoms. The current amphetamine resurgence began. Stuart, FL. Get started on the road to recovery.