
May 18, - Using opioids like Vicodin and OxyContin for chronic pain can be I played competitive tennis; hiked, biked, and ran; worked out; ate “right”. May 27, - Interviewer: Your painkillers don't work for you anymore. be drugs like hydrocodone, and oxycodone, and morphine, Demerol, drugs like that. Apr 15, - Learning how long hydrocodone is active in the body can help you avoid for people with severe pain who need the medication 24 hours a day. Once taken, it begins to work in 10 to 20 minutes, with the peak effects in