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Aug 7, - Vomiting. Other signs of acetaminophen overdose are: Drugs with an 'additive' effect increase Vicodin toxicity by enhancing its sedative and Symptoms and Signs of · What Causes an Overdose? · How to Avoid Overdosing. Hydrocodone Overdose; Acetaminophen Toxicity; Hydrocodone Addiction The exact amount needed to cause an overdose depends on several There are several symptoms of a CNS depression or drug overdose, including the following. Jul 11, - Avoiding Risks of Interactions or Overdose most of these medications is the amount of hydrocodone and acetaminophen in each one. This means that if you take a urine drug screen after being on Norco, it is likely to test.