Weekly Roundup for July 2, 2021: Recent Publications in Women’s Mental Health

By | July 11, 2021

Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.

Deligiannidis KM, Meltzer-Brody S, Gunduz-Bruce H, Doherty J, Jonas J, Li S, Sankoh AJ, Silber C, Campbell AD, Werneburg B, Kanes SJ, Lasser R.JAMA Psychiatry. 2021 Jun 30.

A two-week course of zuranolone was more effective than placebo in women with severe PPD up to 45 days.


The moderating role of resilience resources in the association between stressful life events and symptoms of postpartum depression.

Julian M, Le HN, Coussons-Read M, Hobel CJ, Dunkel Schetter C. J Affect Disord. 2021 Jun 5;293:261-267.

Stressful life events predicted greater symptoms of depression postpartum. Mastery and optimism predicted fewer symptoms of depression postpartum. Mastery moderated the association between stressful life events and symptoms of depression when controlling for previous psychiatric history.


When birth is not as expected: a systematic review of the impact of a mismatch between expectations and experiences.

Webb R, Ayers S, Bogaerts A, Jeli?i? L, Pawlicka P, Van Haeken S, Uddin N, Xuereb RB, Kolesnikova N; COST action CA18211:DEVoTION team.

BMC Pregnancy Childbirth. 2021 Jul 2;21(1):475. Free article.

A mismatch between birth expectations and experiences is associated with birth satisfaction and it may increase the risk of developing postpartumPTSD.


Childbirth Pain and Post-Partum Depression: Does Labor Epidural Analgesia Decrease This Risk?

Parise DC, Gilman C, Petrilli MA, Malaspina D. J Pain Res. 2021 Jun 25;14:1925-1933. Free article.

Although there is evidence suggesting that labor epidural analgesia may reduce risk for PPD, many studies including the meta-analyses did not uphold the hypothesis.


Association between preconception cannabis use and risk of postpartum depression: Findings from an Australian longitudinal cohort.

Cao S, Jones M, Tooth L, Mishra GD. Drug Alcohol Depend. 2021 Jun 25;226:108860.

Compared with no cannabis use, any past-year cannabis use at 3-15 months before pregnancy may be associated with an increased risk of PPD (1.50, 0.99-2.28). Compared with no cannabis use in the first three annual surveys before pregnancy, chronic use (a past year user in ? 2 surveys) was associated with an 80 % higher risk of incident PPD for births in the following 1-4 years (1.80, 1.22-2.68).


“What kind of man gets depressed after having a baby?” Fathers’ experiences of mental health during the perinatal period.

Hambidge S, Cowell A, Arden-Close E, Mayers A. BMC Pregnancy Childbirth. 2021 Jun 29;21(1):463. Free article.

Fathers in this study perceived that perinatal health professionals view ‘mothers as the priority’. It is clear that health professionals need more training on how to recognise that fathers are also important and need support for their mental health.


Perinatal depression prevention through the mother-infant dyad: The role of maternal childhood maltreatment.

Berry OO, Babineau V, Lee S, Feng T, Scorza P, Werner EA, Monk C. J Affect Disord. 2021 Jul 1;290:188-196.

In this study, 32% of 109 pregnant women endorsed childhood maltreatment (CM+). CM+ women versus CM- were less likely to benefit from an intervention to prevent perinatal depression yet still reported an increase in infant daytime sleep.

MGH Center for Women's Mental Health

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